MAGEL2 IS REQUIRED FOR LEPTIN-MEDIATED DEPOLARIZATION OF POMC NEURONS IN THE HYPOTHALAMIC ARCUATE NUCLEUS IN MICE.

Magel2 is required for leptin-mediated depolarization of POMC neurons in the hypothalamic arcuate nucleus in mice.

Prader-Willi Syndrome is the most common syndromic form of human obesity and is caused by the loss of function of several genes, including MAGEL2.Mice lacking Magel2 display increased weight gain with excess adiposity and other defects suggestive of hypothalamic deficiency.We demonstrate Magel2-null mice are insensitive to the anorexic effect of pe

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Somatic Code of Russian and English Linguistic Cultures: Figurative Features of Macroconcepts Zemlya and Earth / Land

The research featured somatic conceptual metaphors in Russian and English linguistic cultures.The article focuses on the macroconcepts of zemlya and earth / land in fiction represented in the Blunt Wraps National Russian Language Corpus and the Guttenberg Library.The research revealed a great number of somatic metaphors of the earth in these lingui

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Active Learning Framework for Improving Knowledge Graph Accuracy

Knowledge graphs are graph-structured data models that provide a robust scheme for representing real-world relational facts with structured triples.The structural and factual information in knowledge graphs are extensively leveraged in various downstream applications.Unfortunately, knowledge graphs often contain incorrect triples due to the automat

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Land Registration, Adjustment Experience, and Agricultural Machinery Adoption: Empirical Analysis from Rural China

Land property security and advanced factor inputs play critical roles in agricultural modernization in developing Fridge Roller Base countries.However, there are unclear relationships between land property security and advanced factor inputs.This study aims to clarify these relationships from the perspective of the differentiation of the realizatio

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